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2009 Grant Recipients

These innovative research projects will have a monumental impact in regard to the
treatment and diagnosis of Lyme disease. Your donation helps scientists and doctors
study various approaches that can one day “turn the corner” on Lyme disease.

M. Karen Newell, Ph.D.
Colorado Springs, CO

One ground-breaking research project that TTC is funding in 2009 is headed by M. Karen Newell, Ph.D. at the University of Colorado at Colorado Springs. Her research has implications for improving quality of life for Lyme patients in the future. This study examines the genetics of chronic inflammation, which is a characteristic of every stage of Lyme disease. Using targeted peptides aimed at those that have the particular "immune response" genes associated with disease, Dr. Newell will attempt to reduce the inflammation caused by the Borrelia bacteria.

Eva Sapi, Ph.D.
West Haven, CT
Dr. Sapi, entering the second year of her two-year grants, has been studying the role of biofilms and nematodes in Borrelia burgdorferi, the bacterial agent of Lyme disease. Dr. Sapi has confirmed that the Borrelia bacteria is capable of hiding within a complex covering called biofilm, which increases its resistance to antibiotic treatment. The next step is to test which agents will ensure that Borrelia cannot hide in biofilm during and after antibiotic therapy. Dr. Sapi strongly believes this research will be vital to treating patients with chronic Lyme disease.

A second study focuses on filarial nematodes, a microscopic worm found in deer ticks, the type that are known to spread Lyme disease. The researchers have identified that at least 40% of the tested deer ticks had this pathogen. The goal of this study is to provide a new means to test Lyme patients for a novel infection and to develop different therapeutic protocols, especially for those patients who are not responding to antibiotics.

Lyme Literacy Programs for Patients
Washington, DC

TTC sponsored several projects to increase awareness of Lyme, including a legislative forum in the nation’s capital, led by the National Capital Lyme and Tick-Borne Disease Association. The forum helped build unity in the Lyme community and to educate many people about the legislative process and what they could do in order for chronic Lyme to be recognized by the United States Congress.